Clinical Biochemistry

School of Biological Sciences

Research Papers Published

• "Structural characteristic of the initial unfolded state on refolding determines catalytic efficiency of the folded protein in presence of osmolytes." PLoS One, 9(10): 1094 -1105
• "Salt Potentiates Methylamine Counteraction System to Offset the Deleterious Effects of Urea on Protein Stability and Function" PLoS One, 10(3): DOI No. 10.1371/j
• "A current perspective on the compensatory effects of urea and methylamine on protein stability and function" Progress in biophysics and molecular biology, 119(2): 129 -136
• "Trimethylamine N-oxide abolishes the chaperone activity of a-casein: an intrinsically disordered protein" Scientific reports, 7(1): 6572 -6579
• "Effect of an Imposed Contact on Secondary Structure in the Denatured State of Yeast Iso-1-Cytochome c" Biochemistry, 56(51): 6662 -6676
• "An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells" International Journal of Biological macrmolecules, 135(1): 77 -87 Impact Factor= 3.929
• "Taurine Induces an Ordered but Functionally Inactive Conformation in Intrinsically Disordered Casein Proteins." Scientific Reports, 10(1): DOI No. 10.1038/s41598-020-60430-7 Impact Factor= 4.53
• "Structural-functional Integrity of Lysozyme in Imidazolium Based Surface Active Ionic Liquids" Int J Biol Macromol, 156(04): 271 -279 Impact Factor= 4.79
• "Comparative Milk Proteome Analysis of Kashmiri and Jersey Cattle Identifies Differential Expression of Key Proteins Involved in Immune System Regulation and Milk Quality" BMC Genomics, 21(1): DOI No. 10.1186/s12864-020-6574-4 Impact Factor= 3.73
• "Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives" Current Protein and Peptide Science, 21(5): 443 -487
• "Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition" The Journal of Physical Chemistry B, 125(6): 1531 -1541
• "Protecting thermodynamic stability of protein: The basic paradigm against stress and unfolded protein response by osmolytes" International Journal of Biological Macromolecules, 177(2): 229 -240
• "Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition" The Journal of Physical Chemistry B, 125(6): 1531 -1541 {ISSN: 1520-6106}
• "Trimethylamine N-oxide alters structure-function integrity of ß-casein: Structural disorder co-regulates the aggregation propensity and chaperone activity" International Journal of Biological Macromolecules, 182(1): 921 -930 {ISSN: 0141-8130}
• "The gut metabolite, trimethylamine N-oxide inhibits protein folding by affecting cis–trans isomerization and induces cell cycle arrest" Cellular and Molecular Life Sciences, 79(1): 1 -16 {ISSN: 1420-682X} Impact Factor= 9.261
• "Urea ameliorates trimethylamine N-oxide-Induced aggregation of intrinsically disordered a-casein protein: the other side of the urea-methylamine counteraction" Journal of Biomolecular Structure and Dynamics, 2053744(1): 1 -8 Impact Factor= 3.392
• "Brain Metabolite, Myo-inositol, Inhibits Catalase Activity: A Mechanism of the Distortion of the Antioxidant Defense System in Alzheimer’s disease" ACS omega, 7(15): 12690 -12700 Impact Factor= 4.132
• "Effect of polyol osmolytes on the structure-function integrity and aggregation propensity of catalase: A comprehensive study based on spectroscopic and molecular dynamic simulation measurements" International Journal of Biological Macromolecules, 209(1): 198 -210 Impact Factor= 8.025

Books Published

• "Proteostasis and Chaperone surveillance". Springer, New delhi Heildelberg New Yprk Drodrecht London. {ISBN: 978-81-322-2466-2} pp 180
• "Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives". Springer Nature singapore Ltd. {ISBN: 9789811037061} pp 250
• "Protein Modificomics: From Modifications to Clinical Perspectives". Academic Press, Elsevier, USA. {ISBN: 978-0-12-811913-6} pp 371
• "The Glycome: Understanding the Diversity and Complexity of Glycobiology". CRC Press. pp 336

Research Projects Details:

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