TANVEER ALI DAR Ph.D

Associate Professor

Deparment of Clinical Biochemistry

University of Kashmir 

tanveerali@kashmiruniversity.ac.in

           

        

     

        

         

Research Areas:

  1. Structural and Functional Characterization of globular proteins and Intrinsically Disordered proteins (IDPs) in presence of Osmolytes/Chemical Chaperones: Focusses on understanding the structural and functional characterization of antioxidant protein systems (Catalase, Superoxide dismutase etc), an important class of enzymes associated with major diseases conditions, and Intrinsically Disordered prtoeins (casein, crystalline etc.) by osmolytes. Elucidating the influence of osmolytes on the two different protein classes may enable us to design solution conditions that may enhance binding of drug targets to these clinically important enzymes. The main motivation is towards technology development for stabilization of Therapeutic/clinically important proteins.
  2. Protein Misfolding/Aggregation/Amyloid formation: Role of chemical chaperones in modulating/regulating the aggregation/amyloid formation of both natively folded and natively unfolded (Intrinsically Disordered Proteins) and understanding their mechanism of action. Identification of the nature of interactions of chemical chaperones with fibrillates/aggregates at different steps of aggregation is a key step towards the discovery and synthesis of target oriented potential inhibitors of these associations.
  3. Medicinal Plant proteomics: Involves the purification and characterization of some novel biologically active proteins from some important medicinal plants like Ashwagandha.  We had already isolated a novel protein from Ashwagandha with anti-cancerous activity, for which we are carrying its further structural and functional characterization. For achieving this goal, our lab is in active collaborations with IIIM, Jammu; ACBR, University of Delhi and CCMB, Hyderabad. The main focus of this research area is towards Development of a Protein drug.  

 

Selected Publications:

  1. Ishfaq Ahmad Ahanger, Owais Hassan Wani, Yueshan Zhong, Syed Hussain Mir, Faez Iqbal Khan, Tanveer Ali Dar, Neurometabolite, myo-inositol, induces conformational distortion with enhanced aggregation of Carbonic Anhydrase: Implications for altered metabolite levels in Alzheimer's disease, Journal Of molecular Structure, 2025:1325, 141054

    2.     Syed Ifrah Manzoor, Farhat Jabeen, Rajan Patel, M Moshahid Alam Rizvi, Khalid Imtiyaz, Maqsood Ahmad Malik, Tanveer A. Dar Green synthesis of biocompatible silver nanoparticles using Trillium govanianum rhizome extract: comprehensive biological evaluation and in silico analysis, Materials Advances 2025: 6 (2), 682-702

    3.     Irfan Ahmad Mir, Hilal Ahmad Mir, Umar Mehraj, Mohammad Younus Bhat, Manzoor Ahmad Mir, Tanveer Ali Dar, Mahboob-Ul Hussain Chloroquine sensitises hypoxic colorectal cancer cells to ROS-mediated cell death via structural disruption of pyruvate dehydrogenase kinase 1, Free Radical Biology and Medicine 2025: 227, 656-666

    4.     Ishfaq A. Ahanger, Tanveer A. Dar. Small molecule modulators of Alpha-Synuclein Aggregation and Toxicity: Pioneering an Emerging Arsenal Against Parkinson's Disease, Ageing Research Reviews, 2024: 102538

    5.     SS Wani, H Qadri, AH Shah, TA Dar. Dual Antifungal and Antiproliferative Activities of a Novel Protein Fraction from a Medicinally Important Herb Trillium govanianum Wall. ex. D. Don. Applied Biochemistry and Biotechnology, 2023:1-19

    6.     H Sharma, TA Dar, YS Wijayasinghe, D Sahoo, NK Poddar. Nano-osmolyte conjugation: Tailoring the osmolyte-protein interactions at the nanoscale, ACS omega (2023) 8 (50), 47367 – 47379

    7.     MY Bhat, IA Mir, M Ul Hussain, LR Singh, TA Dar. Urea ameliorates trimethylamine N-oxide-Induced aggregation of intrinsically disordered α-casein protein: the other side of the urea-methylamine counteraction, J. Biomol. Str. and Dyn. (2023), 41 (8): 3659-3666

    8.     Fasil A., Usma M., Reshmee B., Aniket K.B., Kempohalli SC, Laishram RS, Suma MS, Vladimir U, Tanveer AD. Brain Metabolite, Myo-inositol, Inhibits Catalase Activity: A Mechanism of the Distortion of the Antioxidant Defense System in Alzheimer’s disease, ACS omega (2022), 7 (15): 12690-12700

    9.     Fasil A., Usma M., Faez IK, Dakun L, Md Khurshid AK, Chandrashekharaiah KS, Laishram RS, Tanveer AD. Effect of polyol osmolytes on the structure-function integrity and aggregation propensity of catalase: A comprehensive study based on spectroscopic and molecular dynamic simulation measurements, Int. J. Biol. Macro. (2022) 209, 198-210

    10.  K Kumari, M Warepam, AK Bansal, TA Dar, VN Uversky, LR Singh. The gut metabolite, trimethylamine N-oxide inhibits protein folding by affecting cis–trans isomerization and induces cell cycle arrest, Cellular and Molecular Life Sciences (2022) 79 (1), 1-16

    11.  A Kumawat, S Raheem, F Ali, TA Dar, S Chakrabarty, MA Rizvi Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition. The Journal of Physical Chemistry B (2021) 125 (6), 1531-1541

    12.  MY Bhat, MA Malik, LR Singh, TA Dar Trimethylamine N-oxide alters structure-function integrity of β-casein: Structural disorder co-regulates the aggregation propensity and chaperone activity. International Journal of Biological Macromolecules (2021) 182, 921-930

    13.  MY Bhat, LR Singh, TA Dar (2020) Taurine induces an ordered but functionally inactive conformation in intrinsically Disordered casein proteins, Scientific reports 10 (1), 1-11

    14.  PA Dar, SA Mir, JA Bhat, A Hamid, LR Singh, F Malik, Dar TA. An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells, Int. J.  of Biol. Macro. (2019) 135:77-87

    15.  SS Wani, PA Dar, SM Zargar, Dar TA. Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives. Current Protein & Peptide Science (2020) 21(5):443-487

 

Books published

  1. Singh, Laishram Rajendrakumar, Tanveer Ali Dar, and Parvaiz Ahmad, (2015) eds. Proteostasis and Chaperone Surveillance. Edited Vol. Book; Publisher - Springer (India) Pvt. Ltd ISBN: 978-81-322-2466-2; 978-81-322-2467-9 (eBook), DOI 10.1007/978-81-322-2467-9
  2. Singh, Laishram Rajendrakumar, and Tanveer Ali Dar, (2017) Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives, Edited Vol. (I); Springer (Singapore) Pvt. Ltd. ISBN: 978-981-10-3706-; 978-981-10-3707-8 (eBook); DOI 10.1007/978-981-10-3707-8
  3. Tanveer A. Dar, Singh LR (2019) Protein Modificomics: From modifications to Clinical Perspectives, ISBN: 9780128119136; Publisher: Academic Press, Elsevier, USA pg. 387
  4. Adeel A. Malik and Tanveer A. Dar (2022) Glycome: Understanding the Diversity and Complexity of Glycobiology, Hard ISBN: 9781771889971 E-Book ISBN: 9781003145394, Publisher: CRC Press Pages: 336pp. 
  5. L. Rajendrakumar Singh, Tanveer A. Dar and Kritika Kumari (2024) Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives, Edited Vol. (II) ISBN 978-981-97-6000-8 ISBN 978-981-97-6001-5 (eBook); Springer Nature Singapore Pte Ltd., 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
  6. Tanveer A. Dar, L. R. Singh and Vladimir Uversky (2025) Osmolytes and Intrinsically disordered proteins: From Functional regulation to disease pathogenesis In Progress in Molecular Biology and Translational Science, Academic Press Elsevier, USA ISBN:978-0-443-29320-7

Research Grants:

  1. Biophysical Characterization of glycosylated and non-glycosylated forms of Withania somnifera glycoprotein, a therapeutically important protein from Withania somnifera (Ashwagandha) (DBT, New Delhi)

  2. Design and synthesis of novel multi-target-directed coumarin derivatives as potent anti-Alzheimer and antioxidant compounds (J & K DST)

  3. Evaluation of Polyherbal Unani formulations for their potential to inhibit Acetylcholinesterase and ameliorate β-amyloid toxicity (CCRUM, GOI, New Delhi)

  4. Purification and Molecular Characterization of therapeutically active protein(s)/peptide(s) from an Anti-cancerous protein fraction Isolated from Withania somnifera (L.) Dunal  (DST, New Delhi)

  5. Proteomic studies of Ashwagandha for Identification and Characterization of its anti-cancerous protein(s)/peptide(s): Towards Exploration of novel protein-based drug molecules ((J & K ST&IC)

  6. Comparative Study of the Effect of Osmolytic and Macromolecular Crowders on Protein Structure and Folding (DST, New Delhi)

  7. Investigating the Effect of Osmolytes on Protein Fibrillation  (CSIR, New Delhi)

Lab Members 

Present:

1.     Ishfaq Bashir Hajam
2.     Syed Ifrah Manzoor
3.     Owais Hassan Wani
4.     Umar Rasool
5.     Dr. Ishfaq Ahmad Ahanger (PDF)
6.     Dr. Aadil Rasool (ICMR-RA) 

Past:

         1. Dr. Parvaiz A. Dar

         2. Dr. Mohd. Younus Bhat

        3. Dr. Mashooq A. Dar

        4. Dr. Usma Manzoor

        5. Dr. Snowber Shabir Wani

        6. Dr. Ehsan Abdullah

        7. Anzar Shah

        8. Barhaq Bashir

        9. Shahidah Rahman