Assistant Professor

             

     My area of research is focused on various horizons of plant biochemistry and its application in human health. I have a keen interest in free radical biology, oxidative stress, inflammation, diabetes, cancer biology, therapeutic targets, and medicinal plant based research. My research team work hard for elucidating/verifying various pharmacological properties of traditionally claimed medicinal herbs notably their antioxidant, antiinflammatory, antidiabetic, anti-hyperlipdemic, anti-microbial and anti-cancer potential under well designed experimental set-ups. We employ various in-vitro experiments, in-vivo/animal models and cell lines. Current research highlights the role of enzyme like protein kinases in regulating hyperlipidemia. We try to explore plant compounds that could modulate such kinases and ameliorate diseases associated with hyperlipidemia. We also evaluate the role of various inflammatory markers in the pathology of inflammation and related disorders.  In near future our focus will be to validate the effect of various medicinally active herbal compounds on diseased animal models of diabetes, Alzheimer’s, Parkinson’s, atherosclerosis, inflammation, cancer and various other human ailments so as to find novel therapeutics against them

   11 Research scholars have been awarded PhD under my supervision, 3 PhD research scholars have submitted their thesis, 4 PhD research scholars are ongoing and working on breast cancer. 6 MPhil scholars have already been awarded their degrees. Two PDF (Research Associates) namely Dr Maroof and Dr Wasafa are present working under my mentorship. I am working on many grants received from various funding agencies like DBT, ICMR, CSIR, DST-SERB and DST-J&K. I also published a book entitled: Pharmacogenomics: From Discovery to Clinical Implementation. Elsevier. ISBN: 978-0-443-15336-5. Twelve book chapters are also in my credit. 5 students from different colleges and universities of Kashmir valley have done their internship (project work) under my supervision and three of the students have done their work on breast cancer. I also received many awards like Best Researcher Award (International Scientist Awards on Engineering, Science and Medicine) on 12 & 13- Sept-2020 Trichy India (VDGOODTM). Research Excellence Award on paper published in Journal of Inflammation Research-2020 (Institute of Scholars). I am an active member of IAEC Regional Research Institute of Unani Medicine, Srinagar and Member Research Advisory Committee (RAC) Department of Biotechnology, Central University of Kashmir. I have a well trained research team presently working on various cancers like Breast cancer, liver cancer and colorectal cancer. My 4 research scholars are present working on breast cancer to check various apoptotic pathway in Kashmiri population. We are also analysing methylation analysis, protein and mRNA expression. 

Faculty Details

  • Citations 2838
  • HIndex 26
  • i10 Index 50
  • Mobile 9419972678
  • Email showkatganie@kashmiruniversity.ac.in
  • Resume View



Research Papers Published

  • "In Vitro Antioxidant and Cytotoxic Activities of Arnebia benthamii (Wall ex. G. Don): A Critically Endangered Medicinal Plant of Kashmir Valley" Oxidative Medicine and Cellular Longevity, 2014(792574): 1 -8 Impact Factor= 3.393
  • "Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract" Journal of Environmental Pathology, Toxicology and Oncology, 33(2): 131 -143 Impact Factor= 0.877
  • "Hepatoprotective activity of LC–ESI-MS standardized Iris spuriarhizome extract on its main bioactive constituents" Phytomedicine, 21(1): 1202 -1207 Impact Factor= 2.877
  • "Antihyperlipidemic and Antioxidant Potential of Paeonia emodi Royle against High-Fat Diet Induced Oxidative Stress" ISRN Pharmacology, 2014(182362): 1 -7 Impact Factor=
  • "Molecular linkages between diabetes and Alzheimers disease: current scenario and future prospects" CNS Neural Disord Drug Targets, 13(2): 290 -8 Impact Factor= 3.76
  • "Melatonin:- A potential antioxidant therapeutic agent for mitochondrial dysfunctions and related disorders" Rejuvenation Research, 01(2): DOI No. 1-12 Impact Factor= 3.391
  • "Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight" Biomedicine & Pharmacotherapy, 74(2015): 101 -110 Impact Factor= 2.21
  • "Anti-inflammatory effect of lycopene rich paste extract in the presence of NSAID on carrageenan induced paw oedema" Asian Journal of Plant Science and Research, 5(4): 1 -9 Impact Factor= 0.69
  • "Taxus wallichiana as a Potential in vitro Antioxidant with Good Lethal Effect on Pathogenic Bacterial Strains" American Journal of Phytomedicine and Clinical Therapeutics, 3(3): 209 -221 Impact Factor=
  • "Crataegus songarica methanolic extract accelerates enzymatic status in kidney and heart tissue damage in albino rats and its in vitro cytotoxic activity" Pharmaceutical Biology, 12(2): 1 -9 Impact Factor= 1.241
  • "An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis" Carcinogenesis, 37(4): 385 -396 Impact Factor= 5.35
  • "Gracilone a new sesquiterpene lactone from Tanacetum gracile (Tansies)" Natural product research, 2(49): 1 -8 Impact Factor= 0.919
  • "Genetic diversity and population structure of Rheum species in Kashmir Himalaya based on ISSR markers" Flora, 223(1): 121 -128 Impact Factor= 1.590
  • "Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders" REJUVENATION RESEARCH, 19(1): 21 -40 Impact Factor= 3.664
  • "Sub-Chronic Oral Toxicity Study of Kushta Qalai (A Unique Herbo-mineral Unani formulation) in Wistar Rats" BRITISH BIOMEDICAL BULLETIN, 4(3): 103 -121 Impact Factor=
  • "Efficacy of Aqueous and Methanolic Extracts of Rheum Spiciformis against Pathogenic Bacterial and Fungal Strains" Journal of Clinical and Diagnostic Research, 10(9): 18 -22 Impact Factor= 0.30
  • "Evaluation of Antibacterial, Antifungal and Phytochemical Screening of Solanum nigrum" Biochemistry & Analytical Biochemistry, 6(1): 1 -6 {ISSN: 2161-1009} Impact Factor=
  • "A Current Perspective on the Inhibition of Cholinesterase by Natural and Synthetic Inhibitors" Current Drug Metabolism, 18(1): 1 -16 {ISSN: 1875-5453} Impact Factor= 2.847
  • "Free Radical Scavenging and Cytotoxic Activity of Seed Extracts of Podophyllum hexandrum" Phytothérapie, 5(1): 1 -9 {ISSN: 1624-8597} Impact Factor=
  • "In vitro Antioxidant and RBC membrane Stabilization Activity of Euphorbia wallichii" Free Radicals and Antioxidants, 7(1): 13 -22 {ISSN: 2231-2536} Impact Factor= 0.831
  • "Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats" Pharmaceutical Biology, 55(1): 1849 -1855 {ISSN: 1388-0209} Impact Factor= 1.916
  • "Some nutraceutical properties of fenugreek seeds and shoots (Trigonella foenum-graecum L.) from the high Himalayan region" Food Bioscience, 23(1): 31 -37 Impact Factor= 1.964
  • "Glutathione-S-transferase, Superoxide Dismutase (GST, SOD) Levels, Protein Content and Lipid Peroxidation in Schizothorax plagiostomus under the Infection of Pomphorhynchus in Nallah Sukhnag of Kashmir Valley" Pakistan Journal of Biological Sciences, 20(1): 442 -442 Impact Factor=
  • "Herbal Compounds as Potential Anticancer Therapeutics: Current perspective" Annals of Pharmacology and Pharmaceutics, 2(20): 1 -4 Impact Factor=
  • "Evaluation of Antioxidant and Immunomodulatory Potential of Methanolic Extract of Juniperus squamata Buch.-Ham. ex D.Don" Free radicals and antioxidants, 8(2): 111 -119 Impact Factor=
  • "Hepatoprotective Potential of Elsholtzia densa Against Acute and Chronic Models of Liver Damage in Wistar Rats" Drug research, 7(2): 1 -9 Impact Factor= 0.701
  • "Cancer: Proteomic Drug Targets and Therapeutics" Current cancer drug targets, 17(5): 1 -13 Impact Factor= 3.186
  • "Rheum- spiciforme Royle- the medicinal herb with positive modulatory effect on controlled in vitro oxidative stress" Indian journal of experimental biology, 56(3): 556 -564 Impact Factor= 1.475
  • "Modern Computational Strategies for Designing Drugs to Curb Human Diseases: A Prospect" Current topics in medical chemistry, 1(3): 1 -15 Impact Factor= 3.374
  • "Modulation of Oxidative Stress and Hyperglycemia by Rheum spiciformis in Alloxan Induced Diabetic Rats and Characterization of Isolated Compound" Drug Research, 8(4): 1 -9 Impact Factor= 0.701
  • "Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration" Cellular and Molecular Neurobiology, 4(1): 1 -33 Impact Factor= 4
  • "The effect of Elsholtzia densa methanolic extract modulates inflammation in vitro and in vivo" Oriental Pharmacy and Experimental Medicine, 19(1): 49 -58 Impact Factor= 0.71
  • "Genotoxic effect of two commonly used food dyes metanil yellow and carmoisine using Allium cepa L. as indicator" Toxicology Reports, 7(1): 370 -375 Impact Factor=
  • "Dipsacus inermis Wall. modulates inflammation by inhibiting NF-?B pathway: An in vitro and in vivo study" Journal of ethnopharmacology, 1(1): 1 -15 Impact Factor= 3.414
  • "Dipsacus inermis Wall. modulates inflammation by inhibiting NF-?B pathway: An in vitro and in vivo study" Journal of Ethnopharmacology, 254(112710): 1 -12 Impact Factor= 3.414
  • "Genotoxic effect of two commonly used food dyes metanil yellow and carmoisine using Allium cepa L. as indicator" Toxicology Reports, 7(1): 370 -375 Impact Factor=
  • "Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/ Cytokines and NF?B Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model" Journal of Inflammation research, 13(84): 829 -845 Impact Factor= 4.953
  • "Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats" Drug and Chemical Toxicology, 43(1): 1 -10 Impact Factor= 2.405
  • "Hepatoprotective effects of Meconopsis aculeata extract against CCl4 induced oxidative damage in rats" Advances in Traditional Medicine, 20(1): 1 -10 Impact Factor=
  • "Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats" Journal of Food Biochemistry, 44(30): 1 -14 Impact Factor= 1.662
  • "Prevalence and incidence of helminth infection in some freshwater fishes of Sukhnag stream in Kashmir" Indian Journal of Experimental Biology, 58(1): 788 -793 Impact Factor= 0.783
  • "Occurrence of Helminth Parasites in Schizothorax plagiostomus and Cyprinus carpio communis from Nallah Sukhnag, Kashmir" International journal of Zoological Research, 16(1): 79 -86 Impact Factor=
  • "Toxicological analysis of synthetic dye orange red on expression of NF?B-mediated inflammatory markers in Wistar rats" Drug and Chemical Toxicology, 43(1): 1 -11 Impact Factor=
  • "Ability of Diagnostic Tests to Predict Subclinical Mastitis and Intramammary Infections in Quarters from Lactating Dairy Cows" Research Journal of Agricultural Sciences, 12(6): 1982 -1986 Impact Factor=
  • "Determination of In Vitro Antioxidant and Radical Scavenging Activities of Alcea rosea" Annals of R.S.C.B, 25(7): 1580 -1587 Impact Factor=
  • "Risk factors associated with subclinical mastitis in dairy cows reared in district Ganderbal, Jammu and Kashmir" Journal of Veterinary and Animal Sciences, 52(4): 418 -422 Impact Factor=
  • "Prevalence of Subclinical Mastitis in Dairy Cows of Different Areas of District Rajouri and Poonch of J&K" The Indian Veterinary Journal, 97(11): 27 -31 Impact Factor=
  • "In Silico Tools for Analysis of Single-Nucleotide Polymorphisms in the Bovine Transferrin Gene." Animals, 12(1): 1 -16 Impact Factor= 2.752
  • "Oxidative stress, serum biochemistry and DNA damage of Cyprinus carpio communis naturally infected with helminths." International Aquatic Research, 14(2): 1 -10 Impact Factor= 1.875
  • "In Silico Tools for Analysis of Single-Nucleotide Polymorphisms in the Bovine Transferrin Gene" Animals, 12(6): 1 -16 Impact Factor= 3.231
  • "Oxidative stress, serum biochemistry and DNA damage of Cyprinus carpio communis naturally infected with helminths" International Aquatic Research, 14(1): 13 -22 Impact Factor= 1.875
  • "Immunomodulatory efficacy of Cousinia thomsonii C.B. Clarke in ameliorating inflammatory cascade expressions" Journal of Ethnopharmacolog, 300(115727): 1 -12 Impact Factor= 5.195
  • "In Silico molecular docking and dynamic analysis of natural compounds against major non-structural proteins of SARS-COV-2." Journal of Biomolecular Structure and Dynamics, 40(1): 1 -17 Impact Factor= 5.235
  • "Milk-Compositional Study of Metabolites and Pathogens in the Milk of Bovine Animals Affected with Subclinical Mastitis" Molecules, 27(8631): 1 -23 Impact Factor= 4.927
  • "Biochemical and Computational Assessment of Acute Phase Proteins in Dairy Cows Affected with Subclinical Mastitis" Current Issues in Molecular Biology, 45(7): 5317 -5346 Impact Factor= 3.10
  • "Artificial intelligence and cheminformatics tools: a contribution to the drug development and chemical science" Journal of Biomolecular Structure and Dynamics, 1(7): 1 -19 Impact Factor= 5.235
  • "Exploring the tumor immune microenvironment in ovarian cancer: a way-out to the therapeutic roadmap" Expert Opinion on Therapeutic Targets, 1(1): 1 -20 Impact Factor= 5.8
  • "GC-MS analysis and potential therapeutic efficacy of extracts from Allium humile Kunth in lowering dyslipidemia in wistar rat models" Journal of Ethnopharmacology, 320(117478): 1 -13 Impact Factor= 5.40
  • "Bioactive fractions from Allium humile alleviate the risk of high fat diet induced atherosclerosis in albino Wistar rats by inhibiting protein kinase C" Fitoterapia, 172(105775): 1 -18 Impact Factor= 3.4
  • "Computational tools and databases at the forefront to study geographic and genomic distribution of SARS CoV 2 variants" Network Modeling Analysis in Health Informatics and Bioinformatics, 13(27): 1 -18 Impact Factor= 2.3
  • "Uraria picta: A review on its ethnobotany, bioactive compounds, pharmacology and commercial relevance" South African Journal of Botany, 167(1): 333 -354 Impact Factor= 3.1
  • "Bioactive potential of Lagotis cashmeriana: a study on morphology, phytochemicals, and antioxidant activity" Natural Product Research, 38(2): 1 -5 Impact Factor= 2.2
  • "Studies on the Ameliorative Potential of Rheum Webbianum Rhizome Extracts on 1,2-Dimethylhydrazine (DMH) Induced Colorectal Cancer and Associated Hepatic and Haematological Abnormalities in Swiss Albino Rats" Journal of Ethnopharmacology, 335(5): 1 -11 Impact Factor= 4.8

Books Published

  • "Honey as Component of Diet: Importance and Scope". Springer Nature Singapore Pte Ltd. pp 24
  • "Proteomic studies of Micronutrient Deficiency and Toxicity". Springer Nature Singapore Pte Ltd. pp 30
  • "Biomonitoring and Bioindicators". Apple academic press. pp 20
  • "LNCRNAS AS No 3.33 445 IMPORTANT MEDIATORS FOR DIAGNOSIS, PROGNOSIS, AND POTENTIAL THERAPEUTICS IN LEUKEMIAS, HEPATOCELLUL AR CARCINOMA,Lon g Non-Coding RNA: From Disease Biomarkers to Targeted Therapeutics,". Cambridge 3 Scholars Publishing. pp 25
  • "Long Non-coding Yes 2.50 446 RNA in neurological diseases: A mechanistic insight,Long Non-Coding RNA: From Disease Biomarkers to Targeted Therapeutics,". Cambridge 4 Scholars Publishing. pp 24
  • "Immunogenetic markers as prognostic tools for the management of various human diseases". Elsevier Science. {ISBN: 978-0-323-90250-2} pp 30
  • "Immunogenetic disorders: treatment with phytomedicines". Elsevier Science. {ISBN: 978-0-323-90250-2} pp 41
  • "Understanding the immunogenetics of human viral diseases". Elsevier Science. {ISBN: 978-0-323-90250-2} pp 32
  • "Immunogenetic markers as prognostic tools for the management of various human diseases". Academic Press (Elsevier). {ISBN: 978-0-323-90250-2} pp 30
  • "Immunogenetic disorders: treatment with phytomedicines". Academic Press (Elsevier). pp 41
  • "Understanding the immunogenetics of human viral diseases". Academic Press (Elsevier). pp 32
  • "Pharmacogenomics From Discovery to Clinical Implementation From Discovery to Clinical Implementation". Elsevier Science. {ISBN: 9780443153365} pp 390
  • "Pharmacogenomics in cardiovascular diseases". Elsevier Science. pp 31
  • "Pharmacogenomics in Cancer". Elsevier Science. pp 26
  • "Pharmacogenomics of Pulmonary and Respiratory diseases". Elsevier Science. pp 23
  • "Pharmacogenomics in Viral diseases". Elsevier Science. pp 22
  • "Pharmacogenomics in Gastroenterology". Elsevier Science. pp 26
  • "Crosstalk of multiomics approaches with medicinal plants of therapeutic importance". Academic Press. {ISBN: 978-0-443-23971-7} pp 30
  • "Multiomics in polycystic ovarian syndrome". Academic Press. {ISBN: 978-0-443-23971-7} pp 33
  • "Basics of microfluidics technology". Academic Press. {ISBN: 978-0-443-13782-2} pp 18
  • "Cancer Stem Cells as Promising Nanotherapeutic Targets". Springer. {ISBN: 978-981-97-3545-7} pp 41

Research Projects Details:

Title of the ProjectFunding AgencyDatedAmount (in Rs.)
Protein and gene expressions of IL1ß, NFkB1, NFkB2, PPAR?, NOS2, COX2, TNFa in LPS induced inflammatory response in rats and effect of Cousinia thomsoniiSERB DST27-04-20173,873,200.00
Protein and gene expressions of IL1ß, NFkB1, NFkB2, PPAR?, NOS2, COX2, TNFa in LPS induced inflammatory response in rats and effect of Cousinia thomsoniiDST- SERB27-06-20183,873,200.00

Research Scholars:

NameCourseStatusNature
Parvaiz Ahmad DarM.Phil Awarded Whole Time
Khalid Bashir DarM.Phil Awarded Whole Time
Shaziya Mohammad TantaryM.Phil Awarded Whole Time
Suhail AneesM.Phil Awarded Whole Time
Suhail AneesM.Phil Awarded Whole Time
Shayaq Ul AbeerPh.D Awarded Whole Time
Showkat Ahmad DarPh.D Awarded Whole Time
Showkat Ahmad DarPh.D Awarded Whole Time
Aashiq Hussain BhatPh.D Awarded Whole Time
Muzafar Ahmad BhatPh.D Awarded Whole Time
IrimPh.D Awarded Whole Time
Shafaquat NabiPh.D Awarded Whole Time
Khalid Bashir DarPh.D Awarded Whole Time
Aunjum ReyazPh.D Awarded Whole Time
Ishfaq Shafi KhanPh.D Awarded Whole Time
Aarif AliPh.D Awarded Whole Time
Suhail AneesPh.D Awarded Whole Time
Saima NazirPh.D Awarded Whole Time

Teaching:

DepartmentSubjectCourse TaughtSemester
Clinical Bio-ChemistryMSc. in Clinical BiochemistryClinical Immunology2